I was thinking about powders that you could buy,find or make with the alchemy kit that functioned like poisons with the ability to effect beverages for later use but these would actually help you such as a small boost to strength, dexterity or constitution but with the penalties of the alcohol.
This would be helpful to not only add to the "idiot strength" of imbibing too much alcohol. But even better with say, someone who wanted to role-play a drunken master. Also balance wise it would be just like a potion of bulls strength or less plus have the added int penalty.
Just my two cents